MYELOID NEOPLASIA TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome
نویسندگان
چکیده
Frank G. Rücker,1 Richard F. Schlenk,1 Lars Bullinger,1 Sabine Kayser,1 Veronica Teleanu,1 Helena Kett,1 Marianne Habdank,1 Carla-Maria Kugler,1 Karlheinz Holzmann,1 Verena I. Gaidzik,1 Peter Paschka,1 Gerhard Held,2 Marie von Lilienfeld-Toal,3 Michael Lübbert,4 Stefan Fröhling,1 Thorsten Zenz,1,5,6 Jürgen Krauter,7 Brigitte Schlegelberger,8 Arnold Ganser,7 Peter Lichter,9 Konstanze Döhner,1 and Hartmut Döhner1
منابع مشابه
TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome.
To assess the frequency of TP53 alterations and their correlation with other genetic changes and outcome in acute myeloid leukemia with complex karyotype (CK-AML), we performed integrative analysis using TP53 mutational screening and array-based genomic profiling in 234 CK-AMLs. TP53 mutations were found in 141 of 234 (60%) and TP53 losses were identified in 94 of 234 (40%) CK-AMLs; in total, 1...
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To evaluate the prognostic impact of monosomal karyotype on post-remission outcome in acute myeloid leukemia, we retrospectively analyzed 2,099 patients who had achieved complete remission. Monosomal karyotype was noted in 73 patients (4%). Of these, the probability of overall survival from first complete remission was 14% at four years, which was significantly lower than that reported in patie...
متن کامل[Acute myeloid leukemia].
Acute myeloid leukemia (AML) is a heterogeneous disease that includes subsets with distinct biological, clinical and prognostic features. It has been well established that cytogenetic abnormalities at diagnosis are associated with the biology of the disease and have important prognostic implications. The coexistence of multiple cytogenetic abnormalities designated as complex karyotype (CK) has ...
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In acute myeloid leukemia (AML) the subset with complex karyotype (CK) is traditionally regarded as the worst prognostic group. However, ≥ 3, ≥ 4, or ≥ 5 abnormalities have been variably used for its definition. Recently, monosomal karyotype (MSK) was suggested to indicate an even inferior outcome. We tested which definition fits best to identify the most unfavorable subgroup. After excluding p...
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In acute myeloid leukemia, the karyotype of the leukemic cell is the most powerful predictor of treatment outcome. Approximately 30% of cases of AML have an unfavorable karyotype, and if treated with conventional chemotherapy, a complete response rate of about 50% and a 5-year overall survival of 10% to 20% are expected. Of those in the unfavorable group, almost half will have a complex karyoty...
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